Use nonprescription lidocaine patches exactly as directed. Do not use more or less of it or use it more often or for a longer period of time than directed by the package instructions.
Your doctor will tell you how many lidocaine patches or topical systems you may use at one time and the length of time you may wear the patches. Applying too many patches or topical systems or leaving them on for too long may cause serious side effects. Apply the lidocaine patch or topical system to clean, dry, intact skin as directed. Choose an area where the patch will not be rubbed by tight clothing.
Do not apply the patch or topical system to an open wound or cut, to skin that is irritated or red, or to skin that is affected by a rash, burn, or other skin problem. If irritation or a burning sensation occurs during lidocaine application, remove the lidocaine patch or system and do not reapply it until the irritation is gone.
Prescription patches and topical systems may be cut into smaller sizes with scissors prior to removal of the release liner. Be sure to remove the current patch before you apply a new one. Do not let lidocaine transdermal come in contact with your eyes. If lidocaine transdermal does touch your eye, immediately wash the eye with water or saline and protect the eye until sensation returns.
While you are wearing a lidocaine transdermal patch or system, protect the treated area from direct heat such as heating pads or electric blankets. You can apply the lidocaine 1. Do not bandage the affected area tightly. If you are using the prescription lidocaine 1. If the lidocaine 1. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. This medication is usually used as needed.
New daily persistent headache is a puzzling thing. NDPH is daily headache that starts suddenly and is daily from the outset. Often it happens in people who have never had any sort of headache before.
Patients can often name the exact time the headache started. Sometimes they will report having a cold or viral illness when things started. Other times the headaches will start during a period of stress. Still other times, it will seem like the headache truly came out of the blue.
There are a few things that can act very much like NDPH and need to be considered. Sometimes daily headaches can start after even very mild head trauma. This is generally diagnosed as post-traumatic headache, but it often acts similarly and is treated similarly to NDPH.
Low cerebrospinal fluid pressure headaches, which usually are much worse when upright than lying down, are not always so clearly positional, and can look similar to NDPH. Finally, medication overuse headache can appear to start suddenly though it should not be as sudden as NDPH.
When medication overuse headache masquerades as NDPH it is likely because the medications were used for something other than headache, such as low back pain. While I am speculating, it seems reasonable to assume that some event or series of events sensitizes the trigeminovascular system the network of nerves and blood vessels that transmit pain in the head.
But it is hard to understand why such a sensitization would occur so suddenly, without warning. Also tricky about NDPH is that there is not much consistency in which medications work.
This may be because NDPH is actually more than one entity. It is reasonable to try several medications from different drug classes to maximize your chances of success. Your healthcare professional can help with this. Brennan, M. A wave of brain hyper excitability followed by a wave of inhibition is called cortical spreading depression CSD. CSD is thought to occur in those who have migraine with an aura.
However, it has also been suggested that CSD may even occur in migraineurs without an aura or in those with migraine without aura. I've used the patches for 5 years now, and they are helpful, though somewhat limited because of where my pain is. I have pain in my right torso, neck, jaw and side of face. I cut the patches in strips and apply them to the spots around the chest and back that are most painful. But my doctor said not to use strips on my face and to avoid areas on the neck close to major veins, so I can't use them in some very, very painful places.
Recently a generic version of Lidoderm has come out and I tried it, but found it extremely inferior. The generic patches are flimsy and don't stick as well, plus I found the adhesive irritating, which hasn't been the case with Lidoderm.
The brand drug costs more of course , but I've needed to stick with it ha! Interesting about the generic. Brand Lidoderm is all I use. I haven't needed a refill yet. Lidoderm's adhesive is aqueous based. If you leave one out like I did by accident a used one , outside where it can absorb dew I took one off my knee on vacation once and left one on the dock by accident I think there is something like a gel that swells up on the patch.
Sort of like those Soil Moist bits for gardening that swell up when exposed to water. I remember when Lidoderms were experimental, I read somewhere that getting a good adhesive base was a big challenge and difficult during development. We used to get endless calls from the nursing homes from the nurses about proper placement and improving adhesion in the long term care patients.
This RXlist link gives the inactive ingredients: Quote:. Last edited by mrsD; at AM. Tags lidoderm , pain , patch , phn Thread Tools. BB code is On. Smilies are On. Forum Rules. All times are GMT The time now is PM. NeuroTalk Forums Helping support those with neurological and related conditions. The penetration of lidocaine into intact skin after application of LIDODERM is sufficient to produce an analgesic effect, but less than the amount necessary to produce a complete sensory block. Absorption The amount of lidocaine systemically absorbed from LIDODERM is directly related to both the duration of application and the surface area over which it is applied.
Blood samples were withdrawn for determination of lidocaine concentration during the application and for 12 hours after removal of patches. The results are summarized in Table 1. Mean peak blood concentration of lidocaine is about 0.
Repeated application of three patches simultaneously for 12 hours recommended maximum daily dose , once per day for three days, indicated that the lidocaine concentration does not increase with daily use. The mean plasma pharmacokinetic profile for the 15 healthy volunteers is shown in Figure 1. Distribution When lidocaine is administered intravenously to healthy volunteers, the volume of distribution is 0.
Lidocaine crosses the placental and blood brain barriers, presumably by passive diffusion. Metabolism It is not known if lidocaine is metabolized in the skin. Lidocaine is metabolized rapidly by the liver to a number of metabolites, including monoethylglycinexylidide MEGX and glycinexylidide GX , both of which have pharmacologic activity similar to, but less potent than that of lidocaine.
A minor metabolite, 2,6-xylidine, has unknown pharmacologic activity but is carcinogenic in rats. Excretion Lidocaine and its metabolites are excreted by the kidneys.
The systemic clearance is 0. Single-dose treatment with LIDODERM was compared to treatment with vehicle patch without lidocaine , and to no treatment observation only in a double-blind, crossover clinical trial with 35 post-herpetic neuralgia patients. Pain intensity and pain relief scores were evaluated periodically for 12 hours. The constant type of pain was evaluated but not the pain induced by sensory stimuli dysesthesia.
About half of the patients also took oral medication commonly used in the treatment of post-herpetic neuralgia. The extent of use of concomitant medication was similar in the two treatment groups. It should be applied only to intact skin. LIDODERM is contraindicated in patients with a known history of sensitivity to local anesthetics of the amide type, or to any other component of the product. Cases of methemoglobinemia have been reported in association with local anesthetic use.
0コメント